Highlights: 1/3 of Americans 45 years or older have atherosclerosis. Young and asymptomatic men with calcium deposits in the coronary artery have 12 times higher risk of develop coronary heart disease! Atherosclerosis kills! Atherosclerosis (esp. early stages) is preventable and reversible!
About Richard Cheng, M.D., Ph.D.. Dr. Cheng is director of Cheng Integrative Health Center/Doctor’s Weight Loss Center, Columbia, SC. He is also a Fellow of American Academy of Anti-Aging & Regenerative Medicine and a functional medicine consultant to the Queen Medical Hospital, Doha, Qatar. A medical graduate of Shanghai Medical University, Dr. Cheng served on the clinical staff at the National Center Institute, NIH as well as Chief of Laboratory Medicine, Army Hospital at Ft Jackson.
Brief Introduction: Calcium deposition into tissues other than our bones (called ectopic deposits) are commonly associated with chronic diseases and aging including coronary artery atherosclerosis. Proper nutrition supplements with or without other drug therapies (hormonal balance) can slow down or reverse atherosclerosis. Probably like me, you don’t want to wait to get started on this easy and inexpensive way of slowing down and reversing your CAD and aging process. We are offering you a great opportunity to participate in our clinical study. This is how it works: we will refer you to a local hospital or imaging center to for a Coronary Artery Calcium (CAC) score, a 10-minute, around $100 test which is also very safe. You will then follow our lifestyle counseling and take our TotoCell Nutrition Supplements (a simple powder packet, mix in water or juice and drink once a day). We’ll ask you to repeat the CAC test every 6 – 12 months for a total of 2 years. If you are interested in participating in this project, please email firstname.lastname@example.org or call (803)233.3420 and ask for CAC Project.
Coronary artery atherosclerotic heart disease is the No. 1 killer in America! Coronary calcium deposits are a hallmark of atherosclerosis. Coronary artery calcium score (CAC) is a sensitive, specific and reliable indicator of atherosclerosis. Extensive lab research and preliminary clinical studies show atherosclerosis is primarily a nutrition deficiency disease and nutritional intervention can slow down or reverse atherosclerosis process.
1. Calcium excess is seen in many chronic diseases, in aging process and is involved in the mechanism leading to cell death.
Calcium is an essential nutrient in normal physiology. But increased levels of calcium both intra- and extra-cellularly have been well documented in nearly all chronic diseases and aging.
– The final mechanism for cell death is high level of intracellular calcium (23250754, 2220009).
– Toxins increase intracellular calcium (23160928, 22927718, 23049237).
– ALS, Parkinson’s, Alzheimer’s disease and many other chronic diseases show elevated intracellular calcium (20493207, 21884755, 21697951).
– Calcium channel blockers (CCBs) block the intracellular movement of calcium, thus effectively lowering the intracellular calcium levels. Originally developed as antihypertensive drugs, CCBs have many other effects than blood pressure lowering. CCBs prevent neurological damage from methylmercury in rats (8882354); long-acting CCBs decrease all-cause mortality (10323641, 10923432, 15716708, 19451836), CCBs use is inversely related to prostate cancer incidence (19451836), CCBs decrease cytoplasmic iron accumulation, the latter is implicated in malignant transformation (21860702).
– Ectopic calcifications occur in cancer patients frequently. In a study involving 23 prostate cancer patients, 22 showed prostate calcification (23308170). Women with the highest scores of bone density testing had an increased risk of developing breast cancer (9032046). Mammography on women with breast cancer often have macro and micro-calcifications (23370209).
2. Coronary artery calcium deposition is an integral part of atherosclerotic coronary heart disease.
– One third of Americans 45 years of age or older have arterial calcification (positive CAC)(15337212). Positive CAC not only indicates increased cardiac events and increased all-cause mortality, it also indicates a state of excess calcium load in the body. Anytime overt calcification is seen outside of the bones, a state of excess calcification exists by definition. Logically, a significant degree of calcium excess will be present well before calcium deposition finally occurs (Thomas Levy).
– In a large study involving over 4000 patients and following between 1 and 16 years, Progression of CAC was significantly associated with mortality (21163451).
– Another study involved 938 subjects of 50 years or older with the median follow up of 21.5 months. Cardiovascular or all cause mortality were measured as Hazard Ratios (HR). Compared the CAC 0; CAC 1-100, 3.00; CAC 101-1000, 6.13; CAC >1000, 10.93 (22357989).
– CAC is a sensitive exam to assess atherosclerosis. It is also inexpensive and safe (PMID: 26965738; 16365194; 22357989; 11451257). The radiation dosage of a modern day CAC is only a small fraction of the natural background radiation in the United States. A CAC exam takes less than 10 minutes and costs around $100.
– Any detectable coronary calcium in young, asymptomatic men was associated with a 12-fold increased risk in coronary heart disease (20730016).
– CAC reliably predict not only death from heart disease, but also death from all causes (22357989, 23206921), indicating that the main indicator of extracellular calcium excess, ectopic calcium deposition, reliably predicts increased risk of death from any chronic degenerative disease. This further indicates that the presence of a chronic extracellular calcium excess will reliably indicate secondary chronic intracellular calcium excess.
3. How to reduce coronary calcium excess?
Vit C on calcium. VC plays an essential role in the etiology of atherosclerosis (Levy, T. 2011;
– Men with highest levels of plasma VC had the lowest CAC (15003962).
– Increased inflammatory markers, always associated with lower levels of VC, related to increased progress of CAC (23340891).
– VC promotes calcium solubility (Ruskin, S. 1938. Am J of Dig Dis 5:408-411.)
– People with highest levels of VC have the longest lifespan with reduced all-cause mortality (11247548, 17442130).
Magnesium (Mg) on calcium.
– Mg is a natural antagonist of calcium (Ca) channel blocker (10618948).
– Mg dissolves Ca deposits (2133625).
– Mg deficiency increases intracellular Ca (11811859).
– Mg increases bone density and decreases fracture rates (16274367).
– Mg decreases all-cause mortality (7908076, 12845247).
Vit K2 on calcium.
– activates proteins like osteocalcin and MGP which inhibit ectopic calcifications (22416724).
– helps dissolving existing calcifications (17138823).
– is inversely related to all-cause mortality and aortic calcification (15514282).
– neutralizes Warfarin (which promotes ectopic calcification)(9743228).
– decreases fracture and improves bone quality (19949271).
– decreases cardiac and all-cause mortality (15514282).
Vit D on calcium.
– in therapeutic range, decreases all-cause mortality (19953106, 23446902).
Essential fatty acids on calcium.
– some with calcium channel blocking effect (20206488, 21664114).
– high levels protect bone loss (22392875, 22507833).
– blood levels inversely related to all-cause mortality (20551373).
Estrogen on calcium.
– decreases coronary calcification (22747181);
– the higher the blood level, the lower CAC scores (20512078);
– inhibits a protein that promotes calcification (20595654);
– deficiency increases inflammatory cytokines (11815671);
– lessens incidence of osteoporotic fractures (22612613);
– deficiency increases all-cause mortality (23460719).
Testosterone on calcium.
– deficiency a clear risk factor (2246104);
– deficiency increases all-cause mortality (21143567, 22280063);
– has calcium channel blocking effect (21439799);
– inversely related to CAC (22522505).
Lysine and proline play important roles in atherosclerotic plaque formation and are able to prevent or reduce the plaques. Lysine binds to circulating Lp(a) as well as dislodge Lp(a) that’s bound to atherosclerotic plaque. This makes lysine an additional important supplement for reversing/resolving atherosclerosis (Rath, M. Reducing the risk for cardiovascular disease with nutritional supplements. J of Orthomol Med 7(3):153-162). Lysine + Vit C were repeatedly observed to be able to dramatically reduce anginal chest pain (Linus Pauling).
4. Preliminary clinical studies show atherosclerosis can be slowed or even reversed.
– Katz (1992) reported a case of 62 year old female heart patient. She was given Vit C, proline and lysine along with other supplements. Repeat angiography of her heart showed significant improvement over a period of 19-months.
– Pauling (1991, 1993) reported 2 cases with significant atherosclerotic blockages in their coronary arteries responding very well to vitamin C and lysine. One of them, a 62 years old woman showed a reduction from 75% to 40% of her right coronary artery blockage and from 50% to no blockage of her left coronary artery after 19 months of Vit C and lysine supplementation. The 3rd patient didn’t have visible blockage but clinically responded very well to Vit C and lysine with reduced anginal chest pain.
– Rath and Niedzwiecki in 1996 reported the significant regression of atherosclerosis with nutrition therapy. They reported their study of 55 patients with documented coronary artery disease. They used coronary calcium score as an index of evolving coronary atherosclerosis. They found: annual progression rate without intervention to be 44%; 15% decrease of progression over one year with supplements; No progression with patients with early stages of coronary atherosclerosis. Their nutritional program, however, contained 150 mg calcium and 1.5 mg copper daily. Their vitamin C dose was 2700 mg, Vit D only 600 IU, L-Lysine only 450 mg and L-Proline only 450 mg. And yet a clearly positive response compared to no nutritional intervention was seen.
Summary: Excess calcium accumulation, reflected by ectopic calcium deposits in soft tissues including coronary artery, is an important part of coronary heart disease, many other chronic diseases and aging. Coronary calcium score (CAC) is a sensitive, reliable, safe and inexpensive test to detect the presence, and monitor the progression of, heart disease and aging. Modified and advanced nutrition program including Vit C, Mg, K2, D3, proline, lysine and other vitamins and nutrients can slow down or reverse coronary heart disease.
Most references cited can be found in Pubmed.com with their PMID number in (). References without PMID numbers are listed below.
Levy, Thomas. Primal Panacea. Medforx Publishing. 1st Ed. 2011
Levy, T. STOP AMERICA’S #1 KILLER! Medfox Publishing, 2nd Ed. 2015
Pauling, L. Case report: lysine/ascorbate-related amelioration of angina pectoris. 1991 Journal of Orthomolecular Medicine 6(3&4):144-146.
Pauling, L.Third case report on lysine-ascorbate amelioration of angina pectoris. 1993 Journal of Orthomolecular Medicine 8(3):137-138.
Rath and Niedzwiecki. Nutritional supplement program halts progression of early atherosclerosis documented by ultrafast computed tomography. 1996 J. of Applied Nutrition 48:68-78. http://www4fr.dr-rath-foundation.org/bibliotheque/publications_scientifiques/dr_rath/pub18.html)