Dr. Richard Cheng, Cheng Integrative Health Center

What if one believes in Republican conservative ideology but favors a plant-based diet?  Schizophrenic Diet?

Remember, if this term Schizophrenic Diet takes off, I claim the IP rights. haha

Source of the left image: https://azbigmedia.com/lifestyle/here-are-the-most-popular-diets-in-each-state/

Dr. Cheng’s anti-aging program, daily practical operations and specific nutritional supplements

This article is for informational purposes only. Please use under the guidance of a qualified and experienced doctor. This was originally written in Chinese and I google-translated it into English. I read through to make sure it is accurate, although the English expression may not be the best.

• diet
• sleep
• rest, relaxation
• exercise
• nutritional supplements

After getting up around 6-7 am, I drink a cup of black coffee.

I sit under a red- near infrared light (660nm + 850nm light) source. I usually shine my head or shoulders and upper arms under near-infrared light. I then scan the medical literature for any interesting updates.

Red light illuminates my eyes. I also listened to some news on American politics and culture, and received red light eye therapy (closed my eyes and looked at the light source for 3 minutes every morning).

About an hour after drinking coffee, I drink a morning anti-aging cocktail:

• 5-10 grams of vitamin C powder +  one bag of vitamin K2 + 25 mg (5 dropfuls of 1%) of methylene blue.

I usually don’t eat breakfast. I usuallly drink some black coffee.

Lunch: My first meal of the day is lunch, usually between 12noon and 2pm.  I usually have a big lunch with fatty meat, fish or eggs, cooked in butter, lard, coconut oil and olive oil. I also eat a little bit of leafy greens or cruciferous vegetables. I don’t have sugar at home and I don’t use sugar. I use glycine as a sweetener if desired.

My daily nutritional supplements (prepared in our clinic):

• Vitamin B1, 2 capsules daily (800 mg)
• Vitamin B2, 2 capsules daily (520 mg)
• Vitamin B3 (instant-release niacin), 4 – 6 capsules daily (2,000 – 3,000 mg)
• Vitamin C, 2 – 3 bags daily (10,000-15,000 mg)
• Vitamin D3, 30,000 IU daily
• Vitamin K2, 1 capsule daily (1000 mcg)
• Omega-3 Oil, 4,000 mg daily
• Dr. Cheng’s TotoCell Nutrition (one bag daily)
• Dr. Cheng Liver Detox, 1 bag daily
• Magnesium Glycinate, 2 capsules daily (1200 mg)
• Metformin, 2 tablets (1000 mg) daily
• GlyNAC, one bag

After lunch, I usually take a short break before returning to work

Dinner: I usually have a light, fat-burning (low-carb/keto) dinner around 6-7pm.

Exercise: I usually play badminton 2-3 times a week, 2-3 hours each time.

Before bed, I take another dose of methylene blue (25 mg) along with vitamin C (5 mg), GlyNAC, and butyric acid.

I usually go to bed around 11-12pm.

I would lie in bed and shine red and near-infrared light on my body until I fell asleep. I usually sleep well, staying up all night and not waking up until 6-7am.

• GERD is the leading cause of Barrett’s esophagus. Elevated oxidative stress is a key underlying biochemical feature (1, 2). Esophageal adenocarcinoma (EAC) is the leading form of esophageal malignancy in the United States and other industrialized countries. The incidence of EAC has increased rapidly over the past four decades. Barrett’s esophagus (BE) is the major precancerous lesion of EAC in which metaplastic columnar epithelium replaces the normal squamous mucosa of the lower esophagus. The main risk factors for BE and EAC are chronic gastroesophageal reflux disease (GERD), obesity, and smoking. During the BE-dysplasia-EAC sequence, esophageal cells bear a huge burden of reactive oxygen species (ROS) accumulation and oxidative stress. Although normal cells have a complete antioxidant mechanism to maintain a balanced anti-tumor physiological response, the antioxidant capacity of tumor cells is compromised due to the anti-oxidative response that promotes tumorigenesis. During tumor progression in the GERD-BE-EAC sequence, the accumulation of ROS induces DNA damage, lipid peroxidation, and protein oxidation. Tumor cells adapt to oxidative stress by generating tumor-promoting antioxidant responses that keep oxidative damage below lethal levels while promoting tumorigenesis, progression, and resistance to therapy (1).
• Low-carb/ketogenic diet improves gastroesophageal reflux disease (3). A ketogenic diet can improve heartburn symptoms in several ways. Losing weight has been shown to improve heartburn symptoms and acid reflux, and a ketogenic diet is one of the most effective ways to lose weight and maintain a healthy weight. Sugar has pro-inflammatory effects that may make digestive problems worse. Studies show that restricting sugar and carbohydrate intake (low-carb/fat-burning (ketogenic) diets) can improve heartburn symptoms and acid reflux (4, 5). A high-sugar diet requires normal pancreas function. If your pancreas can’t produce enough enzymes to process the excess sugar, the bacteria in your gut can become unbalanced. The result is an overgrowth of opportunistic bacteria that interferes with nutrient absorption and causes gas, bloating, and increased acidity. The ketogenic diet eliminates these grains and starchy carbohydrates that feed opportunistic bacteria (6, 7, 8). Certain carbohydrates, including grains and other starches, also ferment and produce gas, which can stress the lower esophageal sphincter. Some studies have involved interesting measurements, such as the 24-hour esophageal pH probe test, and concluded that ketosis may improve GERD and reflux symptoms. The antioxidant, anti-inflammatory, and nutritious foods commonly found on a ketogenic diet can be very beneficial in managing heartburn symptoms. The best keto foods for gut healing include bone broth, asparagus, garlic, and apple cider vinegar. Fermented foods like sauerkraut and kimchi can nourish the healthy bacteria in your gut and help restore balance. A lack of stomach acid can also cause the contents to back up into the esophagus. Your stomach needs enough acidity to digest food. Many people with acid reflux don’t make enough stomach acid (9).
• Plasma antioxidants such as selenium, vitamin C, β-cryptoxanthine, and lutein were significantly lower in patients with Barrett’s esophagus (10, 11).
• Dietary antioxidants, including vitamins C and E, beta-carotene, selenium, and zinc, can inhibit oxidation and prevent Barrett’s esophagus and esophageal cancer (12).

1. Peng D, Zaika A, Que J, El-Rifai W. The antioxidant response in Barrett’s tumorigenesis: A double-edged sword. Redox Biol. 2021 May;41:101894. doi: 10.1016/j.redox.2021.101894. Epub 2021 Feb 14. PMID: 33621787; PMCID: PMC7907897.
2. Han D, Zhang C. The Oxidative Damage and Inflammation Mechanisms in GERD-Induced Barrett’s Esophagus. Front Cell Dev Biol. 2022 May 26;10:885537. doi: 10.3389/fcell.2022.885537. PMID: 35721515; PMCID: PMC9199966.
3. Austin GL, Thiny MT, Westman EC, Yancy WS Jr, Shaheen NJ. A very low-carbohydrate diet improves gastroesophageal reflux and its symptoms. Dig Dis Sci. 2006 Aug;51(8):1307-12. doi: 10.1007/s10620-005-9027-7. Epub 2006 Jul 27. PMID: 16871438.
4. Ness-Jensen E, Hveem K, El-Serag H, Lagergren J. Lifestyle Intervention in Gastroesophageal Reflux Disease. Clin Gastroenterol Hepatol. 2016 Feb;14(2):175-82.e1-3. doi: 10.1016/j.cgh.2015.04.176. Epub 2015 May 6. PMID: 25956834; PMCID: PMC4636482.
5. Newberry C, Lynch K. The role of diet in the development and management of gastroesophageal reflux disease: why we feel the burn. J Thorac Dis. 2019 Aug;11(Suppl 12):S1594-S1601. doi: 10.21037/jtd.2019.06.42. PMID: 31489226; PMCID: PMC6702398.
6. Damiano A, Handley K, Adler E, Siddique R, Bhattacharyja A. Measuring symptom distress and health-related quality of life in clinical trials of gastroesophageal reflux disease treatment: further validation of the Gastroesophageal Reflux Disease Symptom Assessment Scale (GSAS). Dig Dis Sci. 2002 Jul;47(7):1530-7. doi: 10.1023/a:1015815102175. PMID: 12141813.
7. Pointer SD, Rickstrew J, Slaughter JC, Vaezi MF, Silver HJ. Dietary carbohydrate intake, insulin resistance and gastro-oesophageal reflux disease: a pilot study in European- and African-American obese women. Aliment Pharmacol Ther. 2016 Nov;44(9):976-988. doi: 10.1111/apt.13784. Epub 2016 Sep 1. PMID: 27582035; PMCID: PMC5048546.
8. Can Keto Help Heartburn? – Keto Lifestyle (ketogenic.com)
9. Wright, J. V., Lenard, L. (2001). Why stomach acid is good for you: Natural relief from heartburn, indigestion, reflux, and GERD. M. Evans.
10. Kubo A, Levin TR, Block G, Rumore GJ, Quesenberry CP Jr, Buffler P, Corley DA. Dietary antioxidants, fruits, and vegetables and the risk of Barrett’s esophagus. Am J Gastroenterol. 2008 Jul;103(7):1614-23; quiz 1624. doi: 10.1111/j.1572-0241.2008.01838.x. PMID: 18494834; PMCID: PMC2735568.
11. Clements DM, Oleesky DA, Smith SC, Wheatley H, Hullin DA, Havard TJ, Bowrey DJ. A study to determine plasma antioxidant concentrations in patients with Barrett’s oesophagus. J Clin Pathol. 2005 May;58(5):490-2. doi: 10.1136/jcp.2004.023721. PMID: 15858119; PMCID: PMC1770670.
12. Kang JH, Luben R, Alexandre L, Hart AR. Dietary antioxidant intake and the risk of developing Barrett’s oesophagus and oesophageal adenocarcinoma. Br J Cancer. 2018 Jun;118(12):1658-1661. doi: 10.1038/s41416-018-0113-y. Epub 2018 May 21. PMID: 29780162; PMCID: PMC6008398

Some of the research papers supporting the inclusion of methylene blue in cancer management.

• Mitochondrial dysfunction is a hallmark of cancer [1–5], various other chronic diseases [6–12] as well as aging [13,14].
• Methylene blue promotes mitochondria energy production by promoting more glycolysis and glutaminolysis to TCA cycle, lower ROS level. MB is a potent redox exchanger acting as an electron shuttle in the mitochondria, bypassing complexes I to III of the ETC and resulting in decreased ROS production [1]
• Aerobic glycolysis or Warburg effect in cancer is well known and has been proposed to be an adaptation mechanism to support the biosynthetic requirements of uncontrolled proliferation [15].
• Disruption of cytochrome c oxidase function induces the Warburg effect and metabolic reprogramming [16]. Methylene blue preserves cytochrome C oxidase activity [17]
• Methylene blue has been shown to kill or inhibit cancer cells in vitro, with or without PBM [18–25]
• MB was shown to be more effective in treating tumors in mice over traditional chemotherapy [26]
• MB, along PBM and toluidine blue has been shown to result in complete resolution of chemotherapy-resistant AIDS-related Kaposi’s sarcoma skin lesions [27]
• MB was discovered in 1876 and is the first synthetic drug for human use. Although MB is FDA approved for human use and has been in clinical use for more than 100 years, clinic
• has been used use for human cancer is limit
• The direct treatment of cancer in humans (only one article). While treating different types of cancer, the author asserted that MB reliably stopped pain secondary to cancer, improved general health, and added years of longevity. This was reported in 1907! [28]
• Another article asserted that MB was found to have anticancer effects over a century ago [29]
• The efficacy of an inexpensive and safe agent like MB in many different and even advanced medical conditions make it an ideal general add-on or even stand-alone treatment most of the time. Furthermore, its potent anti-cancer effects in vitro make it especially puzzling why straightforward clinical studies on cancer patients with MB alone or in combination with other agents have not been reported. Even the positive effects of the much-ignored vitamin C on cancer patients have been published in many articles, yet the wonderful properties of MB have been known much longer now than vitamin C. The literature even suggests that MB could play a positive role in the treatment of cancer patients [30]
• Methylene blue is generally safe without significant side effects [31] and inexpensive.

1. Luo Y, Ma J, Lu W. The Significance of Mitochondrial Dysfunction in Cancer. Int J Mol Sci. 2020 Aug 5;21(16):5598.
2. Hsu CC. Role of mitochondrial dysfunction in cancer progression – PMC [Internet]. [cited 2023 May 6]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950268/
3. Guerra F. Mitochondrial Dysfunction: A Novel Potential Driver of Epithelial-to-Mesenchymal Transition in Cancer – PubMed [Internet]. [cited 2023 May 6]. Available from: https://pubmed.ncbi.nlm.nih.gov/29250487/
4. Seyfried T. Cancer as a mitochondrial metabolic disease – PMC [Internet]. [cited 2023 May 6]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493566/
5. Seyfried T. Cancer as a metabolic disease | Nutrition & Metabolism | Full Text [Internet]. [cited 2023 May 6]. Available from: https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-7-7
6. Diaz-Vegas A, Sanchez-Aguilera P, Krycer JR, Morales PE, Monsalves-Alvarez M, Cifuentes M, Rothermel BA, Lavandero S. Is Mitochondrial Dysfunction a Common Root of Noncommunicable Chronic Diseases? Endocr Rev. 2020 Mar 16;41(3):bnaa005.
7. Mitochondrial Dysfunction: A Common Hallmark Underlying Comorbidity between sIBM and Other Degenerative and Age-Related Diseases – PMC [Internet]. [cited 2023 May 6]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290779/
8. Duarte-Hospital C, Tête A, Brial F, Benoit L, Koual M, Tomkiewicz C, Kim MJ, Blanc EB, Coumoul X, Bortoli S. Mitochondrial Dysfunction as a Hallmark of Environmental Injury. Cells. 2021 Dec 30;11(1):110.
9. Galvan DL, Green NH, Danesh FR. The hallmarks of mitochondrial dysfunction in chronic kidney disease. Kidney International. 2017 Nov 1;92(5):1051–7.
10. The Key Role of Mitochondrial Function in Health and Disease – PubMed [Internet]. [cited 2023 May 6]. Available from: https://pubmed.ncbi.nlm.nih.gov/37107158/
11. Wang Y. Mitochondrial dysfunction in neurodegenerative diseases and the potential countermeasure – PubMed [Internet]. [cited 2023 May 6]. Available from: https://pubmed.ncbi.nlm.nih.gov/30889315/
12. Tyrrell D. Age-Associated Mitochondrial Dysfunction Accelerates Atherogenesis – PubMed [Internet]. [cited 2023 May 6]. Available from: https://pubmed.ncbi.nlm.nih.gov/31818196/
13. Miwa S. Mitochondrial dysfunction in cell senescence and aging – PubMed [Internet]. [cited 2023 May 6]. Available from: https://pubmed.ncbi.nlm.nih.gov/35775483/
14. New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary – PubMed [Internet]. [cited 2023 May 6]. Available from: https://pubmed.ncbi.nlm.nih.gov/36040386/
15. Liberti MV, Locasale JW. The Warburg Effect: How Does it Benefit Cancer Cells? Trends Biochem Sci. 2016 Mar;41(3):211–8.
16. Srinivasan S, Guha M, Dong DW, Whelan KA, Ruthel G, Uchikado Y, Natsugoe S, Nakagawa H, Avadhani NG. Disruption of cytochrome c oxidase function induces the Warburg effect and metabolic reprogramming. Oncogene. 2016 Mar 24;35(12):1585–95.
17. Methylene Blue Preserves Cytochrome Oxidase Activity and Prevents Neurodegeneration and Memory Impairment in Rats With Chronic Cerebral Hypoperfusion – PubMed [Internet]. [cited 2023 May 6]. Available from: https://pubmed.ncbi.nlm.nih.gov/32508596/
18. Anticancer activity of methylene blue via inhibition of heat shock protein 70 – PubMed [Internet]. [cited 2023 May 6]. Available from: https://pubmed.ncbi.nlm.nih.gov/30257315/
19. Combination photodynamic therapy of human breast cancer using salicylic acid and methylene blue – PubMed [Internet]. [cited 2023 May 6]. Available from: https://pubmed.ncbi.nlm.nih.gov/28499173/
20. Wb G, A T, Dm C, M R, Cw V. Inactivation of bladder tumor cells and enzymes by methylene blue plus light. The Journal of urology [Internet]. 1987 Nov [cited 2023 May 6];138(5). Available from: https://pubmed.ncbi.nlm.nih.gov/3669192/
21. Methylene blue and photodynamic therapy for melanomas: Inducing different rates of cell death (necrosis and apoptosis) in B16-F10 melanoma cells according to methylene blue concentration and energy dose – PubMed [Internet]. [cited 2023 May 6]. Available from: https://pubmed.ncbi.nlm.nih.gov/34798348/
22. Lee YS, Wurster RD. Methylene blue induces cytotoxicity in human brain tumor cells. Cancer Lett. 1995 Jan 27;88(2):141–5.
23. Methylene blue photodynamic therapy induces selective and massive cell death in human breast cancer cells – PubMed [Internet]. [cited 2023 May 6]. Available from: https://pubmed.ncbi.nlm.nih.gov/28298203/
24. Methylene blue-mediated photodynamic therapy enhances apoptosis in lung cancer cells – PubMed [Internet]. [cited 2023 May 6]. Available from: https://pubmed.ncbi.nlm.nih.gov/23708127/
25. Methylene blue-mediated Photodynamic Therapy in human retinoblastoma cell lines – PubMed [Internet]. [cited 2023 May 6]. Available from: https://pubmed.ncbi.nlm.nih.gov/34304071/
26. Lai B. [Antitumor effect of methylene blue in vivo] – PubMed [Internet]. [cited 2023 May 6]. Available from: https://pubmed.ncbi.nlm.nih.gov/2806052/
27. Tardivo JP, Del Giglio A, Paschoal LH, Baptista MS. New photodynamic therapy protocol to treat AIDS-related Kaposi’s sarcoma. Photomed Laser Surg. 2006 Aug;24(4):528–31.
28. Slack HR. Methylene Blue in the Treatment of Cancer. Atlanta J Rec Med. 1907 May;9(2):79–83.
29. Brown J. Treatment of cancer with antipsychotic medications: Pushing the boundaries of schizophrenia and cancer – PubMed [Internet]. [cited 2023 May 6]. Available from: https://pubmed.ncbi.nlm.nih.gov/35970416/
30. Yang SH, Li W, Sumien N, Forster M, Simpkins JW, Liu R. Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots. Prog Neurobiol. 2017 Oct;157:273–91.
31. Bistas E. Methylene Blue – StatPearls – NCBI Bookshelf [Internet]. [cited 2023 May 6]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK557593/

We take an integrative approach to disease management especially cancer. Most cancers are caused by carcinogens (toxins). The classic genetic mutation theory of cancer stipulates that carcinogens cause genetic mutations which eventually lead to cancer. However, toxins can cause not only genetic mutations, but also damage many other important biomolecules and cellular organelles, particularly mitochondria. Mitochondria are cell’s energy powerplant and a regulatory center for cell growth and death. We believe cancer is the result of the imbalance of the increasing damaging effects of toxins (carcinogens) and the decreasing protective effects of anti-toxin nutrients. When such imbalance reaches a tipping point, cancer ensues. We also believe treatments aiming at only cancer killing will not deliver results as these approaches only look at the cancer cell, ignoring the more important part, the whole body, our disease fighting defense. Studies upon studies of the FDA approved chemo drugs of the past 20 years show cancer patients do not receive significant benefits (neither improvement of quality of life, nor life extension) from these cytotoxic drugs in a global scale (1). We believe on the one hand, while killing or controlling cancer cell remains an important goal, we need to avoid debilitating “casualties” of those toxic cancer chemotherapies. On the other hand, we need to boost our own cancer fighting immunity by repairing the damages done by those toxins and by other unhealthy lifestyle choices made in the past.

• Lifestyle (spiritual, attitude, sleep, exercise etc)
• Diet:
  • Restricted Ketogenic Diet, Intermittent Fasting
• Nutrition, Orthomolecular nutrition: 
  • Mitochondrial nutrition, antioxidants: High dose Vit C, D3, niacin, methylene blue, NIR light therapy
• Toxins, Detox: Fat soluble vs. water soluble toxins, Chemical and heavy metal toxins, Elimination of toxins, Detox
• Hormonal Balance: Thyroid, adrenal, sex hormones
• Regenerative Medicine (cell and stem cell therapy, etc).
• Others, e.g., lose dose naltrexone (LDN)

1. Studies of the Past ~20 Years Show: Cancer Chemo Drugs Do Not Offer Significant Benefits. http://www.drwlc.com/blog/2022/03/06/studies-of-the-past-20-years-show-cancer-chemo-drugs-do-not-offer-significant-benefits/

Topic:  Unlocking the Potential of Methylene Blue

Time: Apr 4, 2023 10:00 AM US Time (EST)
Apr 4, 2023   4:00 PM Hungary Time
Apr 4, 2023 10:00 PM China Time

Meeting ID: 965 9382 2890
Passcode: MB123

Guests:

• Dr. Laszlo Tretter, Professor of Biochemistry, Semmelweis University, Hungary.
• Thomas E. Levy, M.D., J.D., Consultant, Riordan Clinic.

Host: Richard Z. Cheng, M.D., Ph.D.

Abundant research suggests that methylene blue has the following biological properties. Why wonder? Come join us.

Top 10 benefits of methylene blue + near-infrared (NIR) light:

1. Antidote for chemical poisoning and drug overdose
2. The greatest antimalarial drug ever discovered?
3. Antiviral Warrior
4. Effects on Alzheimer’s and Parkinson’s diseases
5. Boosts Brain Power and Enhances Cognitive Abilities
6. Antidepressant, improve sleep, reduce night anxiety
7. Is hope for autism?
8. Powerful pain relief function
9. Promotes Heart Health
10. Adjuvant cancer therapy

Selected references:

1. Sváb G, Kokas M, Sipos I, Ambrus A, Tretter L. Methylene Blue Bridges the Inhibition and Produces Unusual Respiratory Changes in Complex III-Inhibited Mitochondria. Studies on Rats, Mice and Guinea Pigs. Antioxidants (Basel). 2021 Feb 16;10(2):305. doi: 10.3390/antiox10020305. PMID: 33669457; PMCID: PMC7920423.
2. Tretter L, Horvath G, Hölgyesi A, Essek F, Adam-Vizi V. Enhanced hydrogen peroxide generation accompanies the beneficial bioenergetic effects of methylene blue in isolated brain mitochondria. Free Radic Biol Med. 2014 Dec;77:317-30. doi: 10.1016/j.freeradbiomed.2014.09.024. Epub 2014 Sep 30. PMID: 25277417.
3. Levy, T. Resolving cold with methylene blue. Feb. 4, 2023. http://orthomolecular.org/resources/omns/v19n08.shtml

Anti-Aging Lab Testing

• Complete blood count, urinalysis and fecal analysis
• Comprehensive metabolic panel
  • liver and renal function
  • lipids, fasting blood glucose, fasting insulin, HbA1c,
• Full thyroid function panel, including autoantibodies and anti-T3 (rT3)
• Vitamin D3
• hsCRP, homocysteine (hcy), ferritin (ferritin)
• Bone Densitometry (BDX)
• Coronary artery calcium ion deposition score (CAC)
• Men: PSA and testosterone levels
• Heavy Metal panel
• Environmental Chemical Toxins panels
• Amino acid metabolism test (detection of effects on metabolism and liver detoxification function)
• Stress hormone test
• Comprehensive sex hormone testing

Many, if not all, vitamins and micronutrients do not work alone in our body. They work in synergistic, antagonistic or interdependent manners. While the synergistic and antagonistic actions are well known, the interdependent manner is much less known. Here are some examples of this “interdependency”

1. B vitamins cannot do their job without enough omega-3s, and vice versa: https://foodforthebrain.org/campaigns/alzheimers-prevention/omega-3-and-b-vitamins/#:~:text=associated%20with%20Alzheimer’s.-,B%20vitamins%20found%20not%20to%20work,omega%2D3%20and%20vice%20versa&text=Also%2C%20at%20the%20end%20of,benefit%20from%20the%20B%20vitamins.
2. Young, L.M.; Gauci, S.; Arnoldy, L.; Martin, L.; Perry, N.; White, D.J.; Meyer, D.; Lassemillante, A.-C.; Ogden, E.; Silber, B.; Scholey, A.; Pipingas, A. Investigating the Effects of a Multinutrient Supplement on Cognition, Mood and Biochemical Markers in Middle-Aged Adults with ‘Optimal’ and ‘Sub-Optimal’ Diets: A Randomized Double Blind Placebo Controlled Trial. Nutrients 2022, 14, 5079. https://doi.org/10.3390/nu14235079
3. Liao S, Omage SO, Börmel L, Kluge S, Schubert M, Wallert M, Lorkowski S. Vitamin E and Metabolic Health: Relevance of Interactions with Other Micronutrients. Antioxidants (Basel). 2022 Sep 9;11(9):1785. doi: 10.3390/antiox11091785. PMID: 36139859; PMCID: PMC9495493.
4. Vit D and K on bone health: https://www.foodandnutritionjournal.org/pdf/vol10no3/Nutrition_Vol10_No3_840-857.pdf
5. Non drug intervention on glaucoma: Fahmideh F, Marchesi N, Barbieri A, Govoni S, Pascale A. Non-drug interventions in glaucoma: Putative roles for lifestyle, diet and nutritional supplements. Surv Ophthalmol. 2022 May-Jun;67(3):675-696. doi: 10.1016/j.survophthal.2021.09.002. Epub 2021 Sep 23. PMID: 34563531.

Cardiovascular diseases (CVDs) are the leading cause of death, killing some 18 million people globally, costing more than $320 billion annually in the USA alone. About 2/3 of these deaths are due to heart attacks and strokes, with atherosclerosis the key pathology. Although the causes of CVDs continue to be debated, it is generally accepted in the literature that atherosclerotic CVDs are inflammatory diseases with elevated oxidative stress. Oxidative stress is due to the imbalance of excessive oxidants (toxins) and deficient antioxidants. The resulting deficiency of vitamin C, a primary antioxidant, leads to impairment of collagen synthesis. Collagen plays a critical role in the integrity of arterial walls. Collagen deficiency results in arterial wall damage and an inflammatory response leading to atherosclerosis and associated pathologies including coronary artery stenosis and occlusion.

Based on the review and analysis of decades of research, we have previously proposed an integrative orthomolecular medicine approach that includes healthy lifestyle, nutritional supplementation with a focus on high dose vitamin C and other antioxidants, and toxin avoidance and removal (detox). We report here that with this protocol we have reversed two cases of atherosclerotic CVDs. Existing evidence and clinical experience suggest that atherosclerosis is preventable and reversible.

[The above 32 minute presentation inaugurates the new video arm of the Orthomolecular Medicine News Service. The Orthomolecular Medicine Educational Video Service is free-access, peer-reviewed, and non-commercial.
https://www.youtube.com/channel/UC1dbpz2xB3jhAAyjvLn2yOQ/about
Videos will also be posted on Brighteon at https://www.brighteon.com/channels/OMES
Your comments, corrections and suggestions are invited and may be made directly to <DrCheng@drwlc.com> .]