Integrative Cancer Therapies Introduction

Cancer is not a disease of genetic mutations. It is a disease of metabolic (mitochondrial) abnormalities

For patients with advanced metastatic cancers, we’ve got good news for you.  Call (803)233-3420 to schedule an appointment to see Dr. Cheng today, if you have any questions.

We were all told that cancer is a disease caused by DNA mutations.  Based on this dogma (so called Somatic Mutation Theory), a few initial insulting mutations (so called driver mutations) will start the cancerous process, causing many other mutations in a cell and eventually turn the cell into a cancer cell. So all the daughter cancer cells should bear the same driver mutation fingerprints.  The scientists have been searching for these driver mutations for the past decades.  If we could find these driver mutations, then we should be able to develo unique drugs to target them and kill them all.  This was the holy grail for scientists.  Starting in the mid 1990s, DNA sequencing became rapid and inexpensive.  Scientists mapped the whole human genome in the 1990-2000 era (the Human Genome Project).  Very quickly, scientists also sequenced many cancers (The Cancer Genome Atlas, TCGA).  But to our dismay, we did not find the driver mutations everyone was looking for. A driver mutation is a grand father mutation that causes a cell to turn into cancer cell, so it must be present in all (at least the majority) of cancer cells.  But scientists have not found even one such driver mutation.  Yes, cancer cells display numerous DNA mutations.  But these mutations vary greatly from cancer to cancer.  Even in the same patient, cancer cells from the same tumor mass show different mutations.  All in all, no one can find any specific mutations that are present in a majority (let alone all) cancer cells. This has really frustrated all cancer research scientists.

Actually not all scientists believed this driver mutation theory.    Dr. Pete Pedersen of Johns Hopkins University and Dr. Thomas Seyfried of Boston College are among the leaders of a few scientists who believed that cancer is a metabolic disease, a disease not caused by the DNA mutations, but caused by the mitochondrial damage.  This is a very old theory, proposed by the late Dr. Otto Warburg, a Nobel laureate, back in the 1920s.  Warburg observed that while normal cells can burn both glucose and fat as fuel, most, if not all, cancer cells use glucose as their only or primary fuel.  Normal cells burn glucose through 2 pathways: anaerobic glycolysis or fermentation (i.e., in the absence of oxygen, glucose is converted to pyruvate and lactate with minimal energy production). But whenever oxygen is present, glucose is mostly burned through oxidative phosphorylation, OxPhos, in the mitochondria, which produces 18 times more energy than the fermentation process.  However, Warburg observed that cancer cells, even in the abundant presence of oxygen, uses mostly anaerobic glycolysis to produce energy.  This phenomenon is known as the Warburg Effect.  The PET scan we use for cancer diagnosis today is based on this glucose preference of cancer cells: cancer cells use far more glucose than normal cells as fuel.  Hence, radio-labeled glucose is injected into a patient which is then taken up mostly by the cancer cells.  The radio-label lights up the cancer cells like a Christmas tree.

The Major Problems with the Current Gold Standard of Cancer Therapies

  1. For the past several decades, since Nixon’s War on Cancer, the cancer treatment result (commonly measured as 5-year survival) for most cancers (esp. cancers of solid tissues like the liver, lungs, pancreas and colon) has not changed much (PMID: 15630849), despite the much money and manpower put into this War on Cancer.  The progress on cancer has been mostly on early diagnosis and early surgical removal of cancers, very limited on chemo or radiaton therapy of advanced cancers.
  2. The theory (Somatic Mutation Theory) based on which the current cancer drug development/treatment is based is seriously being challenged and, very likely, outright wrong.
  3. Cancer stem cells.  All cells including cancer cells come from stem cells.  When stem cells divide to give rise to 2 daughter cells, one usually goes dormant while the other keeps diving.  Current chemo/RAD don’t kill these stem cells. Cancer stem cells are a major source of drug resistance and disease relapse.
  4. The current chemo/RAD therapies for cancer are often too toxic and don’t kill stem cells (above).  This approach aims only to kill the enemy cells and do nothing to boost patient’s own defense.

Cancer Metabolic Therapies

Based on this theory that cancer cells mostly rely on glucose as fuel, one can devise a strategy to “starve” cancer cells by limiting their fuel supply (cutting off sugar and carbs in their diet and increase healthy fats as the fuel, or so called Ketogenic Diet), as well as using glycolysis inhibitors (to further block fermentation pathway of cancer cells).  This approach will seriously reduce the energy supply to the cancer cells while the normal cells are unaffected.  Using this approach (or some variation of it), people have achieved very promising results worldwide.  Here is a short list of some selected reports:

  1. Slocum et al reported (Metabolic Therapeutics Conference, 2/4/17,  Tampa FL) their result of treating 44 cases of stage 4 lung cancer (NSCLC) using a combination of chemo/RAD and metabolic therapy.  The 1-year survival rate of this group of patients was 86.1% (compared to 18% in the literature, PMID 3096514).
  2. The same group (Slocum et al) reported 82.6% 1-year survival for a group of 33 cases of stage 3/4 pancreatic cancers, compared to 20% 1-year survival of combined stages 1-4 in the literature (Slocum et al., J of Pancreas, 2016 Jan. 08, 17(1)36-41).
  3. A case report: an 81 year-old woman diagnosed of stage 3 rectal cancer is still in clinical remission 27 months (by the time or report) after using chemo and metabolic therapy (Slocum et al. 2016).
  4. Roger D was diagnosed of stage 3 bladder cancer in June 2016.  He chose not to get any chemo/RAD, instead he started ketogenic diet in July.  In a short few months, he was in clinic remission (personal communication).
  5. Linda Nabeling of Case Western U reported over 20 years ago 2 cases of advanced brain tumor (stages 3/4) in 2 young girls (3 and 8 years old).  They were given only months, if not a few short years, to live.  These girls were first treated with chemo/RAD with severe side effects and later switched to metabolic therapy (ketogenic diet), both girls were still well (with no clinical sign of cancer) and alive 9 and 15 years later (with the most recent follow up data).
  6. Melanie Schmidt of Wurzburg Germany reported a 16 case 3-months trial of ketogenic diet.  Those who followed the diet were found to have tumor either not progressing or reduced in size.
  7. Eugene Fine of Albert Einstein Medical School reported 10 cases back in 2012 of going on ketogenic diet.  PET-CT showed no progression or or even reduction in tumor size.
  8. Beth Zupec-Kaniay applied ketogenic diet to 10 brain cancer patients. All showed improvement and some even achieved long time survival.
  9. Ko and Pedersen of the Johns Hopkins University applied 3-bromopyruvate (3-BP) to a late stage gastric cancer with liver metastasis (with 95% liver damage) and severe ascites to a young boy.  The boy’s doctor predicted he won’t survive until the next birthday.  The boy’s father, out of desperation, found Ko and Pedersen team. They used 3-BP for the patient and the patient achieved complete remission: no sign of cancer cells anywhere!  The patient survived more than 2 years and eventually died of pneumonia due to poor liver function, not due to cancer recurrence.  At autopsy, no cancer cells were to be found anywhere.
  10. Aasmund, a young Norwegian athlete, was found a 10cm lymphoma (mediastinum), 5 years ago..  After a few toxic rounds of chemo without much success, he gave up on chemo and switched to metabolic therapy.  He is under my care now.  He still has a tumor mass of 3.5 cm but is asymptomatic now.  He is only on metabolic therapy, not on any conventional chemo or RAD.
  11. Joey, a 44 year-old woman of Hong Kong, was found (2016) to have stage 4 breast cancer with metastasis to the lungs, liver, left supraclavicular lymph node and vertebral bodies.  She was also given a few months to live.  She received a few rounds of chemo and also added metabolic therapy.  Her disease is currently stable, with left supraclavicular lymph node disappeared, breast ulcerating mass healing, and the tumor shrinking.  She is otherwise feeling fine with no apparent symptoms.
  12. Csaba Toth reported a patient with oral cancer.  The patient declined all surgical, chemo/RAD and went on ketogenic diet. 20 months later, the tumor reduced in size (confirmed by MRI) and the patient is fine without any side effects or symptoms.
  13. Dr. Zuccoli reported a case of his mother with brain tumor (glioblastoma multiforme).  Knowing how bad the cancer is, Dr. Z convinced his mother to go on ketogenic diet.  Within a few months, her cancer was nowhere to be found (confirmed by MRI).  She stayed on ketogenic diet and the cancer remained under control (MRI).  But then when she went off the ketogenic diet, the cancer came back.

Other Anti-Cancer Therapies

  1. Vitamin C.  Large dose Vitamin C has been used in cancer treatment for a long time. When used properly, large dose IV Vit C (Gonzalez et al., J of Orthomolecular Medicine V30, No.1, 2015);
    1. Can improve patient’s quality of life;
    2. Reduces side effects due to chemo/RAD;
    3. Reduces viral/bacterial/fungal complications of cancer patients as well as improves the symptoms of a patient’s Vit C deficiency and inflammation;
    4. Can kill cancer cells via
      1. Competitive inhibition of glucose uptake by the cancer cells;
      2. Reduce the oxidative stress in a cancer cell, with Vit C being an electron donor;
      3. Kills cancer cancer cells via H2O2 produced by Vit C.
    5. Increases collagen synthesis, improves the immunity.

Our Integrative Cancer Therapies

We believe that cancer is a chronic disease and can/should be managed as such. We take an integral approach to cancer treatment with 2 goals:

  1. Any methods that kills cancer cells without significant side effects, including conventional chemo/radiation therapy.
  2. Boosting patient’s own health using anti-aging/functional medicine approach. This very important part of the treatment has been largely ignored by the conventional cancer therapies in the past.

Specifically, we use an integral approach to treat cancers (esp. advanced stage cancers) using the Restricted Ketogenic Diet + Glycolysis Inhibitors + Broad Spectrum Nutritional Supplementation + Large Dose IVC.  If you have any questions, please schedule an appointment by calling 803.233.3420 to come to talk to Dr. Cheng.

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Whey Protein/VC/MitoSuppport Weight Loss Plan:

WheyProtein/VC/MitoSupport Weight Loss Plan.

Vitamin C is structurally very similar to glucose.  When you ingest a large dose of Vit C, it tricks your body to release insulin.  Vit C also seems to have an appetite suppression capability and many people on large dose Vit C alone report weight loss.  (I am one of these people.  For many years, I tried to lose about 10 lbs to look better but without much success.  Months ago, when I started large dose daily Vit C program, I am talking about ~15 grams of Vit C plus the MitoSupport, I lost 8-9 lbs within 2 weeks and have never gained that weight back).  Vit C is a powder toxin neutralizer and grandfather of anit-oxidants.  Large dose of Vit C is very safe.  The only side effect of Vit C is GI intolerance, watery diarrhea, called Vit C flush.  Vit C has been used as a healthy colon cleanser once a week.

MitoSupport.  Mitochondria are a structure inside of every one of our cells.  It functions as a rechargeable battery within our body.  Malfunction of mitochondria has been found to be responsible for many diseases including autism, heart disease and dementia, as well as aging.  Some natural supplements such as alpha Lipoic acid, CoQ10, L acetyl-carnitine are found to be able to improve mitochondrial function by improving their quality (and probably even increase in quantity as well).  I personally have been very interested in anything that will help my sports insurance and energy level.  I have been taking these MitoSupport supplements for the past few months, I felt significant improvement in my energy level and in my endurance.  Some of you may know that I have been playing badminton against people half of my age or younger (mostly college students or grad students).  You know how desperate I am in searching for power enhancing supplements.  I am glad I found them.  Now I am passing my research results onto you.

Whey protein.  Whey protein is nutrient rich with lots of essential amino acids.  It helps our muscle building and immune system boost.

When we combine these 3 together, we have a powerful weight loss program.

Instructions:

For the First Week:

1. One tablespoonful of the Liver Detox mix, mix in cool or room temperature water (do not use warm or hot water as it will clump whey protein), drink 3 times a day as meal replacement.  You may also make smoothies with this protein mix.

2. Eat plenty of green leafy veggies, to include esp. cruciferous veggies (such as broccoli, cabbage or cauliflower).

3. Drink plenty of water, or tea (green tea preferred without adding sugar or other junks).

4. Do not eat any other foods, such as meats or carbs.

5. Do not eat any food 3-4 hours before bed time.  Give yourself a 12 hour break between the last meal and the first meal of the next day.  This 12-hour period is important for your body esp. mitochondria to digest and process the food load.

From the Second Week:

1. Breakfast: Mix one tablespoonful of Weight Management mix in room temperature or cool water or make a smoothie out of it.  Drink once or twice a day (You’ll need an extra bag of Weight Management Formula, if you plan to use it twice a day).

2. Take 1 teaspoonful (~5gm) of Vit C, dissolve in <4 oz warm water, drink twice a day.  On the weekend, choose a day that you plan to stay home, mix 2-3 teaspoonfuls of Vit C, dissolve in ~ 4 oz warm water and drink it.  Don’t dissolve in too much water, as the sour liquid is not as pleasant as a beer or soda, although quite tolerable.  The goal of this weekend higher dose of Vit C is to produce a Vitamin C Flush: a mild diarrhea (but not uncomfortable) to cleanse your colons.  So start from ~10 grams and work your way up.  The amount of Vit C to produce a mild diarrhea varies between people and also depends on how much toxins you accumulated in your colons.  Once you start taking Vit C regularly, you’ll need less Vit C.

3. For lunch and dinner: If possible, skip dinner.  Eat a 15 gram protein (lean meats or fish or protein powder), plus plenty of green leafy veggies, to include esp. cruciferous veggies (such as broccoli, cabbage or cauliflower).

4. Drink plenty of water, or tea (green tea preferred without adding sugar or other junks).’

5. Do not eat any food 3-4 hours before bed time.  Give yourself a 12 hour break between the last meal and the first meal of the next day.  Try to eat natural real foods, not the processed, canned or prepared foods.  Cut out the sodas or other sugary drinks.  This 12-hour period is important for your body esp. mitochondria to digest and process the food load.

6. Exercise, both aerobic and anaerobic types.

 

 

 

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New Weight Loss Products

Dr. Cheng has spent last few years focusing on anti-aging medical research.  Dr. Cheng received his certification from American Academy of Anti-Aging & Regenerative Medicine.  As a result of his study and research, he has developed several new products based on the principles of anti-aging medicine.

1. Liver Detox Program.  This is a one-week liver detoxification program.  All of us, especially those weight loss patients, should go on a liver detox program several times a year.  We are surrounded by all kinds of chemicals, pesticides and herbicides.  US has over 80,000 registered chemicals, the effects on the human body of many of these chemicals are unknown or unresearched.  These toxins are stored in our body, including the fat tissues.  When we lose weight, these toxins are released that make us uncomfortable.  Detox in early phase of a successful weight loss program is critical.

2. WheyProtein/C/MitoSupport Program.

Vitamin C is structurally very similar to glucose.  When you ingest a large dose of Vit C, it tricks your body to release insulin.  Vit C also seems to have an appetite suppression capability and many people on large dose Vit C alone report weight loss.  (I am one of these people.  For many years, I tried to lose about 10 lbs to look better but without much success.  Months ago, when I started large dose daily Vit C program, I am talking about ~15 grams of Vit C plus the MitoSupport, I lost 8-9 lbs within 2 weeks and have never gained that weight back).  Vit C is a powder toxin neutralizer and grandfather of anit-oxidants.  Large dose of Vit C is very safe.  The only side effect of Vit C is GI intolerance, watery diarrhea, called Vit C flush.  Vit C has been used as a healthy colon cleanser once a week.

MitoSupport.  Mitochondria are a structure inside of every one of our cells.  It functionas as a rechargeable battery within our body.  Malfunction of mitochondria has been found to be responsible for many diseases including autism, heart disease and dementia, as well as aging.  Some natural supplements such as alpha Lipoic acid, CoQ10, L acetyl-carnitine are found to be able to improve mitochondrial function by improving their quality (and probably even increase in quantity as well).  I personally have been very interested in anything that will help my sports insurance and energy level.  I have been taking these MitoSupport supplements for the past few months, I felt significant improvement in my energy level and in my endurance.  Some of you may know that I have been playhing badminton against people half of my age or younger (mostly college students or grad students).  You know how desperate I am in searchign for power enhancing supplements.  I am glad I found them.  Now I am passing my research results onto you.

Whey protein.  Whey protein is nutrient rich with lots of essential amino acids.  It helps our muscle building and immune system boost.

When we combine these 3 together, we have a powerful weight loss program.

3. Optimal Nutrients Program.  We now offer a custom formulated vitamins/nutrients optimal for our health based on the state of the art anti-aging medicine theory.  The unique features of this product are listed below.

  • It contains a full spectrum of all the vitamins, including A, B complex, C, D3, E, K2, CoQ10, Astaxanthin, and Resveratrol, as well as Omega-3 Fish oil.
  • It also contains powerful anti-oxidants: Astaxanthin, Resverarol, and Omega-3 Fish Oil
  • High Dose Vitamin C.  Vitamin C is the grand father of anti-oxidants.  Vitamin C is safe at any dose.  High dose vitamin C has been used in treatment of degenerative diseases such as diabetes, atherosclerosis, cardiovascular diseases, osteoporosis, and arthritis.  High dose (usually intravenous or liposomal Vit C) has been used in cancer treatment.

 

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Cancer Protection and Reserval Protocol

Dr. Thomas Levy, a well known physician, in his book Death by Calcium outlines the following:

  1. Minimize new toxin exposure.
  2. Eradicate acute and chronic infections.
  3. Eliminate accumulated toxins.
  4. Improve or normalize critical regulatory hormones (sex, thyroid).
  5. Optimize antioxidant and nutrient levels, especially vitamin C, throughout the body.
  6. Selectively and appropriately use prescription medications.”

Further: Dr. Levy suggests the following:

Vit C

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Excerpt From: Thomas E. Levy. “Death by Calcium.” MedFoxPub, 2013-12-04. iBooks.
This material may be protected by copyright.

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Insulin Resistance (IR)

 

 

imageInsulin Resistance is a proatherogenic state.

Diagnosing IR:

  • Moderate Elevation of GTT and ALT
  • Metabolic Syndrome (also called Insulin Resistance Syndrome)
  • Fasting blood sugar level: 100-125.
  • TG/HDL > 3.5 (Caucasians); >3 (Mexican Americans); >2.0 (non-Hispanic Blacks).
  • A1c >6.5%
  • GTT is the gold standard.
    • 2 Hour GTT 120-139: 66% loss of Beta cell function.
    • 2 Hour GTT <140 but One hour GTT >125, high probability of IR.
  1. IR damages arteries regardless of blood sugar levels
    1. IR increases arterial inflammation
    2. IR immediately and progressively drives endothelia inflammation
    3.  Majority of MI (myocardial infarction) have IR.
    4. Majority of ACS (acute coronary syndrome) patines are Insulin Resistant.
    5. IR significantly increases ischemic stroke risk in non-diabetic adults.
    6. GGT and ALT predict new onset DM and identify underlying IR
      1. These levels of GGT and AT doubled the risk:
        1. GGT women >/=21 units/L vs. </= 6 units/L;
        2. GGT men >/=47 units/L vs. </=10 units/L
        3. ALT women >/= 20 units/L vs. </=10 units/L
        4. ALT men >/= 34 units/L vs <15 units/L
    7. Ethnicity:
      1. TG (triglycerides)/HDL >/= 3.5 = IR in Caucasians
      2. TG/HDL >/= 3.0 = IR in Mexican Americans
      3. TG/HDL >/= 2.0 = IR in Non-Hisanic Blacks.
    8. Abnormal fasting blood glucose identifies IR
      1. ADA definition: 100-125 mg/dl is abnormal and is a strong indicator of IR
      2. 2 Hour GTT:
        1. Increased risk for IR if >/= 125 mg/dl
        2. If >150, 13x greater risk of IR.
      3. ADA: A1c 5.7 – 6.4% = Pre-diabetes = IR

 

Source: Dr. Jeff Life, A4M Convention 12. 2015, Las Vegas

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Happy Holidays! the office will close on Thursday 12/24/2015, reopen on Monday 12/28/2015. For next week, our office will close on Thursday 12/31/2015, reopen on Monday 01/04/2016.

This week, the office will close on Thursday 12/24/2015, reopen on Monday
12/28/2015. For next week, the office will close on Thursday 12/31/2015, reopen on
Monday 01/04/2016.

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Evidence shows low energy sweeteners help reduce energy intake and body weight

Use of low energy sweeteners (LES) in place of sugar, in children and adults, leads to reduced calorie intake and body weight – and possibly also when comparing LES beverages to water – according to a review led by researchers at the University of Bristol published in the International Journal of Obesity. For the first time, all available science was integrated into a single review to evaluate the real impact of LES, such as saccharin, aspartame, sucralose and stevia, on energy intake (EI) and body weight (BW) over the short– and long–term. A considerable weight of evidence confirmed that consuming LES   instead of sugar helps reduce relative energy intake and body weight.

University of Bristol Research News, 11/16/2015

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Gut bacteria could be blamed for obesity and diabetes

An excess of bacteria in the gut can change the way the liver processes fat and could lead to the development of metabolic syndrome, according to health researchers. Metabolic syndrome is a group of conditions including obesity, type 2 diabetes, high blood pressure, high blood sugar and excess body fat around the waist. People experiencing three or more of these conditions are considered to have metabolic syndrome and are vulnerable to liver and heart diseases. Approximately 20 to 25 percent of adult Americans have the syndrome, according to the American Heart Association. Research supported by the National Institutes of Health has recommended that Americans add more fiber to their diets because higher fiber diets have been found to improve many aspects of health. However in a certain segment of the population, this advice could be doing more harm than good. “It is a common misconception that plant–derived dietary fiber contains zero calories,” said Matam Vijay–Kumar, assistant professor of nutritional sciences and medicine at Penn State. While it’s true that neither people nor mice can digest plant–derived fiber, their gut bacteria can readily ferment the fibers and then release them as energy–rich short–chain fatty acids, such as acetic acid. Once they reach the liver, these compounds convert into lipids and add to fat deposits that could potentially lead to the development of metabolic syndrome, especially in people and mice lacking toll–like receptor 5 (TLR5). TLR5 is a receptor for bacterial flagellin and is part of the innate immune system that maintains gut–bacteria homeostasis, keeping gut bacteria from over–proliferating. Approximately 10 percent of the human population has a genetic mutation in TLR5, resulting in a complete lack of its function, according to Vijay–Kumar. These individuals have a weakened immune system that may increase the risk of developing metabolic syndrome.

Pennsylvania State University Health and Medicine News, 11/03/2015

 

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Gut microbes: Burning calories while you sleep?

Study links changes in gut bacteria to lower resting metabolic rate and weight gain in mice. A University of Iowa study in mice shows that drug–induced changes to the gut microbiome can cause obesity by reducing the resting metabolic rate – the rate at which calories are burned while sleeping or resting. The findings, published in the journal eBiomedicine, highlight the critical role of gut microbes in energy balance and suggest that unhealthy microbiome shifts can lead to weight gain and obesity by altering resting metabolism.

Source:The University of Iowa Health News, 12/18/2015

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Low Cholesterol

While we are all worried about high cholesterol, low cholesterol is bad also. If your cholesterol is below 140, you will not make your sex hormones (DHEA, estrogen progesterone, testosterone for both men and women).

Causes of Low Cholesterol:

  • Immune decline
  • Chronic hepatitis
  • Cholesterol lowering drugs
  • Essential fatty acid deficiency
  • Liver infection or disease
  • Manganese deficiency
  • Adrenal stress
  • Recreational drugs (cocaine, marijuana)
  • Excessive exercise (esp. in females)
  • Low fat diets
  • Psychological stress
  • Cancer

 

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