Bone Health and Osteoporosis, an Orthomolecular Perspective

Posted on August 6, 2022 by Dr. Cheng

by Richard Z. Cheng, M.D., Ph.D., Thomas E. Levy, M.D., J.D.

Summary: Osteoporosis, like most other disease, is caused by not just Vitamin D deficiency, but by many other factors. But the central dogma has been promoting just prescription drugs and calcium supplements. This strategy sounds simple and straight, unfortunately not only they don’t work, they may even be harmful to you.  There is a rich body of data in the literature that show lifestyle, nutrition, toxin and hormonal balance (or lack thereof) have an impact on bone health and osteoporosis. A brief summary of these research data is presented here.  The practical management of osteoporosis, and other chronic diseases, should incorporate these aspects for optimal results.

The recent issue of NEJM published an article showing Vit D supplementation does not improve osteoporosis. 1 Forbes magazine immediately jumped the gun: Stop Taking Vitamin D Already! 2

Vitamin D is more than just a vitamin, it is more like a hormone with pleiotropic effects on human, including immune boosting effects to fight against Covid-19. Declaring to stop taking Vit D based on just one negative study is not only unscientific, it’s against common sense.  (I will not discuss the study design issues, as Dr. Bill Grant will offer his critique of NEJM’s poor study design soon). There have been many clinical studies on Vit D3 and Covid-19 in the last 2 years, including a special collection of Micronutrients for Viral Infections – Reference Bibliography by International Society for Orthomolecular Medicine, 3 and several such papers on Orthomolecular Medicine News Service including a recent review by Dr. Bill Grant. 4 Have the author and editor of the Forbes article either not been updated on the Vit D research or is there something else?

Prescription drugs and calcium supplements have no significant benefits on osteoporosis.

Earlier this year, a meta-analysis published on JAMA found that bisphosphonates, a major class of prescription osteoporosis drugs offer very few benefits to osteoporotic patients. 5 Another meta-analysis on JAMA showed calcium supplements do not offer significant help to osteoporosis. 6

Calcium supplements increase your risks of cardiovascular diseases and cancer.

To make matters worse, calcium supplements not only do not improve your health, but may actually increase your risks of cardiovascular diseases and cancer, as reported on a recent study. 7

There are actually many studies in the literature demonstrating the increased risks of calcium supplements, as elegantly summarized by Thomas Levy, M.D., J.D.8 9

Prescription drugs and calcium supplements are not helpful and may be even harmful.  So, are osteoporosis patients doomed?

Not at all. There is a rich body of evidence in the medical literature showing that osteoporosis is a multifactorial disease, and a healthy lifestyle, toxin overload (hence detoxification), optimal nutrition and hormonal balance are effective in improving not only osteoporosis but your overall health. I’ll summarize these findings below. 8

Highlights of some of the relevant research:

  • Vitamin C and Osteoporosis:
    • Increased oxidative stress (= inflammatory response) in the bone is accompanied by an increase in C-reactive protein (CRP). CRP can accurately predict fracture risk in older women with osteoporosis.10
    • Increased other inflammatory markers are also closely associated with increased fracture risk. 11
    • High-dose vitamin C can significantly reduce CRP and many other markers of inflammation. 12
    • Vitamin C stimulates the development of osteoblasts.13 14
    • Vitamin C is necessary for the synthesis of progenin (class III), which is required for the growth of osteoblasts. 15
    • Dietary vitamin C, which is negligible compared to any form of vitamin C supplementation, does not reduce fracture risk.16
    • Elderly osteoporosis patients with a history of fractures had significantly lower levels of vitamin C than those without a history of fractures.17
    • Supplementation with vitamin C, but not calcium, significantly increased bone mineral density in all bones.18
    • In ovariectomized mice, vitamin C prevents bone loss.19Vitamin C significantly accelerates fracture healing (PMID: 11510911).
    • Vitamin C significantly improves the strength of healed fractures.20
  • Magnesium deficiency and osteoporosis:
    • Magnesium is a natural calcium antagonist.21 22
    • Magnesium dissolves calcium deposits in soft tissues.23
    • Magnesium deficiency leads to an increase in intracellular calcium. 24
    • Magnesium increases bone density and reduces fractures.25
    • Magnesium reduces all-cause mortality.26 27
    • Usual supplemental doses have no toxic side effects.
  • Vitamin K deficiency and osteoporosis:
    • Inhibits ectopic calcification by activating proteases such as osteocalcin and matrix Gla proteins.28
    • Helps dissolve deposited calcium.29
    • Neutralizes warfarin (warfarin can cause ectopic calcification). 30
    • Reduced fracture risk. 31
    • Improves bone quality. 32
    • Reduces cardiac and all-cause mortality. 33
    • At any dose tried, there was no apparent toxicity. 34
  • Vitamin D deficiency and osteoporosis
    • A normal level of vitamin D ensures that the body gets enough calcium from the diet.
    • The role of vitamin D goes far beyond the metabolism of bone and calcium.
    • Vitamin D regulates about 2000 genes. 35
    • Deficiency of vitamin D leads to osteoporosis. 36
    • Too much vitamin D exacerbates osteoporosis. 37
    • During bone growth and development, it plays an important role in bone density. 38
    • Reduced all-cause mortality at therapeutic doses of vitamin D. 39 40
  • Estrogens and Osteoporosis:
    • Reduce coronary calcium deposition. 41
    • The higher the E2, the lower the CAC score. 42
    • Inhibits a calcification-promoting protease. 43
    • Estrogen deficiency leads to an increase in cytokines that promote inflammation. 44
    • Reduction of fracture risk in patients with osteoporosis. 45
    • Estrogen deficiency increases all-cause mortality. 46
    • Estrogen deficiency promotes metabolic syndrome. 47
  • Androgens and Osteoporosis:
    • Testosterone deficiency is a well-established fracture risk factor. 48
    • With calcium channel blocking function. 49
    • Prostate cancer patients often have low testosterone levels (PMID: 22068548).
    • Testosterone levels are inversely proportional to coronary calcium index. 50
    • Testosterone deficiency increases all-cause mortality. 51 52
  • Thyroid hormones and Osteoporosis:
    • Thyroid hormones have a significant effect on the metabolism of cells throughout the body. 53
    • Early skeletal development and the highest bone mass (Peak Bone Mass) have essential roles. 54
    • Both high and low thyroid function increase fracture risk. 55
    • TSH has a direct (non-thyroid-related) bone-protecting function. 56 57
    • Both too high and too low thyroxine independently increased all-cause mortality. This includes subclinical hypothyroidism and subclinical hyperthyroidism. 58 59
    • Thyroid hormones status should be a part of routine medical examination, and should be checked regularly (at least annually), especially in the elderly population.
  • Essential Fatty Acids (EFA) and Osteoporosis:
    • Some EFAs have calcium channel blocking capabilities. 60 61
    • Numerous EFAs have been shown to protect bone mineral density. 62 63
    • Blood EFA levels are inversely related to all-cause mortality. 64
    • Not toxic, may cause gastrointestinal discomfort in large quantities.
  • Calcium Supplements Are Not Only Unhelpful, They Are Harmful: Chronic Hypercalcemia Is Common in Adults, and Calcium Supplements Promote Coronary Calcium
    • A more recent study (2017) showed that calcium supplementation has no effect on osteoporosis. 6
    • One-third of Americans over the age of 45 have CT-detected arterial calcification. 65
    • Coronary heart disease is positively associated with osteoporosis. 66
    • Aortic calcification is positively associated with osteoporosis (PMID: 16704561). 67
    • Calcium supplements promote coronary calcium deposition.
    • A recent 10-year large study of 5448 subjects in the United States found that calcium supplementation was 22% more likely to be positive for CAC (coronary calcium index) than those who did not. CAC has been generally recognized as a reliable predictor of atherosclerotic plaque burden, coronary heart disease, and all-cause mortality. 68 69 70
    • A recent (2022.6) meta-analysis once again showed that calcium supplements increase the risk of cardiovascular disease. 7
  • Significant calcifications outside the bones: indicating calcium excess
    • Ectopic calcifications are very common in cancer.
    • Using the latest MRI, 22 of 23 prostate patients were found to have prostate calcification. 71
    • Excessive intracellular calcium is associated with cancer:
    • The relationship between intracellular calcium and cancer is well established. Higher intracellular calcium concentration increases cancer cell growth and metastasis. 72 73 74
    • Conversely, a drop in intracellular calcium reduces cancer cell metastasis. 75
    • Women with the highest scores on a bone density test had an increased risk of breast cancer. 76
    • Calcifications are usually seen on mammography in patients with breast cancer. 77
    • Calcium and calcium channel blockers (CCBs. Also known as calcium ion antagonists, which have the effect of reducing intracellular calcium ions).
    • Calcium channels are proteins on the cell membrane that selectively allow calcium to enter and leave the cell.
    • CCBs were originally used to treat high blood pressure (which has a vasodilatory function), but are now used for a variety of diseases.
    • The only serious side effect of CCBs is excessive calcium antagonism, resulting in vasoconstriction disorders and hypotension.
    • The hypotensive and other therapeutic effects of CCBs can only be demonstrated on the basis of increased intracellular calcium. Although different CCBs have other different effects, their main function is to block calcium channels. Therefore, we can conclude that any disease for which CCBs are effective is due to the increased intracellular calcium ion concentration affected by the disease.
    • In addition to high blood pressure, CCBs are also effective against the following conditions:
    • Coronary spasm (PMID: 21389642);
    • Angina pectoris (PMID: 23016717):
    • Anti-atherosclerotic (PMID: 22653165);
    • Pulmonary hypertension (PMID: 20543192);
    • Raynaud’s phenomenon (PMID: 21704799);
    • Acute Brain Injury (PMID: 22854593).
    • Epilepsy (PMID: 19303743);
    • Chemotherapy-induced peripheral neuritis (PMID: 23206755):
    • Alzheimer’s Disease (PMID: 21925266):
    • Parkinson’s disease (PMID: 22387374):
    • Osteoporosis (PMID: 21881574):
    • CCBs reduce all-cause mortality (PMID: 10323641; 10922432; 15716708; 19451836).
    • Further evidence that increased intracellular calcium leads to increased intracellular oxidative stress (toxicity):
    • CCBs can prevent methylmercury-induced nerve damage in rats (PMID: 8882354);
    • The use of CCBs is inversely related to the occurrence of prostate cancer (PMID: 23280547);
    • CCBs reduce intracytoplasmic iron accumulation and further increase the increase in intracellular oxidative stress. The accumulation and increase of intracellular iron are also important factors in the carcinogenesis of cells (PMID: 21860702).

To put these altogether, we recommend an integrative management of osteoporosis to include at least the following:

  1. Healthy lifestyle
    1. Sufficient sleep, exercise, outdoor activities and relaxation
    2. Nutrition rich anti-inflammatory healthy diets to include low carbohydrates, sufficient proteins and healthy fats; minimize processed foods and synthetic food additives, agricultural chemicals, antibiotics and hormones, and other environmental pollutant.
  2. Nutrition: In addition to what’s described above, macro- and micro-nutrients play a significant roles in the prevention and reversal of bone health and osteoporosis, as reviewed in 78. Broad spectrum optimal vitamins and micronutrients, esp. vitamin C, D3, K2, and magnesium, as these nutrients require each other for optimal effects, as described in 79.
  3. Toxins and detox. Environmental toxins are major category of root causes to our health.
  4. Hormonal balance. Monitoring the status of the thyroid, adrenal and sex hormones and balance if indicated, is another under-recognized area in medicine today.

References:

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