大剂量静脉注射维生素C（IVC）治疗急性胰腺炎。
我最近照顾了一位急性胰腺炎亲人（男性，84岁）。主䜣5个小时的持续性上腹痛后，他被送入一上海三甲医院急诊室。淀粉酶明显升高，白细胞升高，CT显示胰腺炎症反应明显。送入ICU。除常规支持治疗外，在我要求下，医生同意每天大剂量Vit C（IVC）10克，静脉点滴。 患者病情迅速缓解，第3天腹痛消退，淀粉酶恢复正常。他在第5天出院回家修养。整个过程，患者无任何其他器官并发症。此老年患者严重急性胰腺炎，恢复迅速，顺利。除了患者本身的良好的健康状态，医护人员的悉心照料外，大剂量维生素C静脉点滴的作用不能忽略。
Bansal等报道了一组39例确诊为重症急性胰腺炎的患者中，其中约18-20％在第7天出现器官功能障碍，平均住院时间为13-15天，平均疼痛持续时间为5天（2-8天)（Bansal， 2011年[21546719]。这些患者中有一半接受1克/天 IVC。IVC组和对照组之间未见统计学差异，但IVC使用剂量太少。
另一项研究，将84名急性胰腺炎患者分为2组，治疗组（接受IVC 10 gm /天，持续5天）和对照组（IVC 1 gm /天，持续5天）。与对照组相比，治疗组在各种指标上有统计学意义的明显改善，55小时内腹痛消失，79小时内淀粉酶正常化。治疗组住院时间为9.34天，对照组住院时间为13.45天。 Du，2003 [14606098]。
维生素C有強大的中和毒素，抗氧化，抗微生物(anti-microbial)作用。急性胰腺炎的主要问题是各种胰酶的释放，导致正常组织的被消化破坏，以及继发的高氧化压力的问题。维生素C的在急性胰腺炎治疗中的可能机制包括，阻止脂肪氧化，中和毒素，促进细胞免疫等。我的病人的各种指标的恢复较上述报道中病人要更迅速，且无任何并发症，后遗症。再次显示维生素C的临床用途。维生素C十分安全，廉价，有效。建议所有读者，医生高度重视！(关于更多的维生素C，请参考我们编写的多本书及文章)。
成长 医学博士 生物化学博士
07/16/19于上海
The administration of large dose IV Vit C (IVC) in the treatment of acute pancreatitis.
In a group of 39 patients diagnosed of severe acute pancreatitis, 2 died and
37 were discharged between days 3 and 22. About 18-20% of them developed organ dysfunctions on day 7, the mean hospital stay was 13-15 days, the mean duration of pain was 5 days (2-8 days)(Bansal, 2011 [21546719]. These patients were divided into 2 groups, one of which received 1 gm of IV Vit C. No statistical difference was seen between the IVC group and the control group.
A group of 84 acute pancreatitis patients were divided into 2 groups, Treatment group (received IV Vit C 10 gm/day for 5 days) and Control group (IV Vit C 1 gm/day for 5 days). Treatment group improvement was statistically significant compared to the Control group, with disappearnace of abdominal pain within 55 hours, normalization of amylase within 79 hours. The hospital stay was 9.34 days for the Treatment group and 13.45 days for the Control group. Du, 2003 [14606098].
I recently took care of an acute pancreatitis patient (male, 82). After 5 hours of persistent epigrastric pain, he was admitted to the ICU. his amylase was 2800 and CT scan showed diffuse pancreatic secretions. He was given IV Vit C (IVC) 2 grams the first day in addition to conventional support care. IVC was increased to 12 grams on day 2 and maintained at 10 grm/day for 3 more days until discharge. His abdominal pain subsided gradually and disappeared on day 3, his amylase also reduced to normal. He was discharged on day 5 to home care.